The synthetic division table is:
$$ \begin{array}{c|rrrr}-5&1&2&-22&-45\\& & -5& 15& \color{black}{35} \\ \hline &\color{blue}{1}&\color{blue}{-3}&\color{blue}{-7}&\color{orangered}{-10} \end{array} $$The solution is:
$$ \frac{ x^{3}+2x^{2}-22x-45 }{ x+5 } = \color{blue}{x^{2}-3x-7} \color{red}{~-~} \frac{ \color{red}{ 10 } }{ x+5 } $$Step 1 : Write down the coefficients of the dividend into division table. Put the zero from $ x + 5 = 0 $ ( $ x = \color{blue}{ -5 } $ ) at the left.
$$ \begin{array}{c|rrrr}\color{blue}{-5}&1&2&-22&-45\\& & & & \\ \hline &&&& \end{array} $$Step 1 : Bring down the leading coefficient to the bottom row.
$$ \begin{array}{c|rrrr}-5&\color{orangered}{ 1 }&2&-22&-45\\& & & & \\ \hline &\color{orangered}{1}&&& \end{array} $$Step 2 : Multiply by the number on the left, and carry the result into the next column: $ \color{blue}{ -5 } \cdot \color{blue}{ 1 } = \color{blue}{ -5 } $.
$$ \begin{array}{c|rrrr}\color{blue}{-5}&1&2&-22&-45\\& & \color{blue}{-5} & & \\ \hline &\color{blue}{1}&&& \end{array} $$Step 3 : Add down last column: $ \color{orangered}{ 2 } + \color{orangered}{ \left( -5 \right) } = \color{orangered}{ -3 } $
$$ \begin{array}{c|rrrr}-5&1&\color{orangered}{ 2 }&-22&-45\\& & \color{orangered}{-5} & & \\ \hline &1&\color{orangered}{-3}&& \end{array} $$Step 4 : Multiply by the number on the left, and carry the result into the next column: $ \color{blue}{ -5 } \cdot \color{blue}{ \left( -3 \right) } = \color{blue}{ 15 } $.
$$ \begin{array}{c|rrrr}\color{blue}{-5}&1&2&-22&-45\\& & -5& \color{blue}{15} & \\ \hline &1&\color{blue}{-3}&& \end{array} $$Step 5 : Add down last column: $ \color{orangered}{ -22 } + \color{orangered}{ 15 } = \color{orangered}{ -7 } $
$$ \begin{array}{c|rrrr}-5&1&2&\color{orangered}{ -22 }&-45\\& & -5& \color{orangered}{15} & \\ \hline &1&-3&\color{orangered}{-7}& \end{array} $$Step 6 : Multiply by the number on the left, and carry the result into the next column: $ \color{blue}{ -5 } \cdot \color{blue}{ \left( -7 \right) } = \color{blue}{ 35 } $.
$$ \begin{array}{c|rrrr}\color{blue}{-5}&1&2&-22&-45\\& & -5& 15& \color{blue}{35} \\ \hline &1&-3&\color{blue}{-7}& \end{array} $$Step 7 : Add down last column: $ \color{orangered}{ -45 } + \color{orangered}{ 35 } = \color{orangered}{ -10 } $
$$ \begin{array}{c|rrrr}-5&1&2&-22&\color{orangered}{ -45 }\\& & -5& 15& \color{orangered}{35} \\ \hline &\color{blue}{1}&\color{blue}{-3}&\color{blue}{-7}&\color{orangered}{-10} \end{array} $$Bottom line represents the quotient $ \color{blue}{ x^{2}-3x-7 } $ with a remainder of $ \color{red}{ -10 } $.