Step 1: Write second polynomial below the first one. Making sure like terms are lined up.
$$ \begin{array}{lrrr} & -6x^2 & x & -6 \\ \color{red}{ - } & 4x^2 & -6x & -4 \\ \hline \end{array} $$Step 2: Change ALL the signs in the second row.
$$ \begin{array}{lrrr} & -6x^2 & x & -6 \\ \color{red}{ - } & -4x^2 & 6x & 4 \\ \hline \end{array} $$Step 3: Combine like terms (add each column):
$$ \begin{array}{lrrr} & -6x^2 & x & -6 \\ \color{red}{ - } & -4x^2 & 6x & 4 \\ \hline & -2x^2 & -5x & -10 \end{array} $$