Rewrite $ -4x^{2}+81 $ as:
$$ -4x^{2}+81 = 81 -4x^2 = (9)^2 - (2x)^2 $$Now we can apply the difference of squares formula.
$$ I^2 - II^2 = (I - II)(I + II) $$After putting $ I = 9 $ and $ II = 2x $ , we have:
$$ -4x^{2}+81 = (9)^2 - (2x)^2 = ( -2x+9 ) ( 2x+9 ) $$