The GCD of given numbers is 1.
Step 1 : Find prime factorization of each number.
$$\begin{aligned}321 =& 3\cdot107\\[8pt]427 =& 7\cdot61\\[8pt]\end{aligned}$$(view steps on how to factor 321 and 427. )
Step 2 : Put a box around factors that are common for all numbers:
$$\begin{aligned}321 =& 3\cdot107\\[8pt]427 =& 7\cdot61\\[8pt]\end{aligned}$$Note that in this example numbers do not have any common factors.
Step 3 : Multiply the boxed numbers together:
Since there is no boxed numbers we conclude that $~\color{blue}{ \text{GCD = 1} } $.
This solution can be visualized using a Venn diagram.
The GCD equals the product of the numbers at the intersection.